Adipokines in obesity and metabolic diseases

Adipose tissue secretes many adipokines that regulate important physiological functions. Growing studies have highlighted these bioactive molecules may contribute to the development of metabolic and cardiovascular diseases. Adipokines exert systemic effects independent activity on numerous cells system, including cardiomyocytes vascular cell walls. Adiponectin shows anti-inflammatory anti-atherosclerotic blood vessels. Conversely, resistin is endowed with pro-inflammatory stimulates proliferation smooth muscle cells, thus promoting atherosclerotic plaque. Leptin plays an role in cardiac remodeling pressure regulation through activation sympathetic system. Obesity a pathological condition associated hypertrophy white adipose tissue, which production while, it reduces adipokines. The delicate balance among pro-and generated by affects, not only complications obesity, but also onset progression atherosclerosis. Therefore, be regarded as potential agents clinical interest treatment wide range disorders biomarkers useful for early detection metabolic, inflammatory